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Efficacy Evaluation for new drugs
New Drug
Development Support
Development Support
In Vitro Efficacy Evaluation
In vitro Efficacy Evaluation
| T cell | |
|---|---|
| Activation | IL-2 production |
| Proliferation | BrdU incorporation & CFSE dilution |
| Differentiation |
Th1 (IFN-γ + T-bet) Th2 (IL-4 + GATA-3) Th17 (IL-17A + RORγT) Treg (IL-10 + Foxp3) |
| Macrophage | |
|---|---|
| Activation | Maturation phenotyping |
| Differentiation |
M1 (MHC-IIhigh, TNF-α, CCR-7) M2 (CD206, Arg-1, CCL-22) |
| Myofibroblast | |
|---|---|
| Activation |
α-SMA expression Collagen I expression |